30.01.2019     13:00

Neurobiology / SFB1134 Lecture

 

Physiology of the myelin sheath, beyond speed and precision

Maarten H.P. Kole
Netherlands Institute For Neuroscience,
Amsterdam, The Netherlands

Myelination is a key development in the evolution of the vertebrate nervous system and spans many orders of magnitude. At the microscopic scale, myelin is recognized as the spirally wrapped multilamellar membranes forming an insulating sheath around axons which has its main functional impact at the mesoscopic scale; the acceleration of action potentials to minimize conduction delay times in long-range neural circuits. The specific physiological properties of internodes remain, however, poorly understood.

Using an array of techniques including imaging of calcium in the myelin sheath, electrophysiological recordings from oligodendrocytes, neurons and interneurons, combined with computational modeling and EM, we investigated both normal myelin development and toxin-induced demyelination of the somatosensory cortex in adult rodents. Collectively, I will show how our findings are in support of the emerging view that myelin has functional roles beyond speed and temporal precision, revealing cell-type specific differential shaping of excitation and inhibition in local circuits of the sensory cortex.

HS2
Im Neuenheimer Feld 306, Heidelberg

 

06.02.2019   13:00

IZN Seminar

 

Recruitment of pyramidal cells with dendritic axon origin into neuronal ensembles

Christian Thome (AG Draguhn)

 

Age- and NMDAR-dependent effects of hypoxia-ischemia on hippocampal function

Dimitri Hefter (AG Gass)

 

HS2
Im Neuenheimer Feld 306
Heidelberg

 

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Heidelberg Brain Health Forum 2019

25.3.2019

Physics Institute
Klaus Tschira Building
Im Neuenheimer Feld 226
69120 Heidelberg

Speakers:

Giles Hardingham (University of Edinburgh, UK)

Stuart Lipton (Scripps Research Institute, La Jolla, USA)

Lynn Raymond (University of British Columbia, Vancouver, Canada)

Arndt Rolfs (Centogene AG, Rostock, Germany)

Jürgen Scheuermann (ETH Zürich, Switzerland)

Organiser: Hilmar Bading

More information to follow


Human blood cells can be directly reprogrammed into neural stem cells

Foto © M.C. Thier/DKFZ

Scientists from the German Cancer Research Center (DKFZ) and the stem cell institute HI-STEM* in Heidelberg have succeeded for the first time in directly reprogramming human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the early embryonic development of the central nervous system. They can be modified and multiplied indefinitely in the culture dish and can represent an important basis for the development of regenerative therapies.

Together with stem cell researcher Frank Edenhofer from the University of Innsbruck and neuroscientist Hannah Monyer from DKFZ and the Heidelberg University Hospital, Andreas Trumpp (German Cancer Research Center (DKFZ) and Director of HI-STEM in Heidelberg) and his team have succeeded in reprogramming different human cells: connective tissue cells of the skin or pancreas as well as peripheral blood cells. "The origin of the cells had no influence on the properties of the stem cells," said Marc Christian Thier, first author of the study. In particular, the possibility of extracting neural stem cells from the blood of patients without invasive intervention is a decisive advantage for future therapeutic approaches. More...


Erfolgreiche Forschung zu Multipler Sklerose: 2,7 Millionen Euro für die nächste Förderperiode

DiemBei Multipler Sklerose (MS) greift das Immunsystem körpereigenes Nervengewebe an, Nervenzellen sterben ab. Könnte ein gestörter Kalzium-Haushalt der beteiligten Zellen Ursache und Antrieb der chronischen Erkrankung sein? Dieser zentralen Frage geht die Forschungsgruppe 2289 der Deutschen Forschungsgemeinschaft (DFG) unter Federführung von Professor Dr. Ricarda Diem, Neurologische Universitätsklinik Heidelberg, und Professor Dr. Veit Flockerzi, Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, nach. Beteiligt sind Wissenschaftlerteams aus Heidelberg, Homburg und Hamburg-Eppendorf. Die DFG unterstützt die Forschungsgruppe "Kalzium-Homöostase bei Neuroinflammation und -degeneration" für weitere drei Jahre mit insgesamt 2,7 Millionen Euro. Mehr...


Highly Cited Researchers 2018

Highlycitedresearchers2018


Four IZN Investigators included in the list of world-class researchers selected for their exceptional research performance, demonstrated by production of multiple highly cited papers that rank in the top 1% by citations for field and year in Web of Science.


EMBL researchers discover that four organs in a marine worm’s head can sense different chemicals

Internal anatomy of a marine worm’s head. In blue is seen the individual cell nuclei and all nervous fibres are seen in green. IMAGE: Thomas Chartier and Wiebke Dürichen /EMBL

We sense the world around us using primarily our eyes, ears and nose. Marine worms, on the other hand, have long been thought to understand the world very differently – primarily by detecting chemicals in the ocean water that surrounds them – although this has not been investigated in detail. Now, researchers in the Arendt group have recorded nerve cell activity in the head of marine worms. The worm’s small size and transparency, means that all of the nerves and neurons within the head can be imaged at once. They found that these cells located in four particular areas of the head reacted when the worms were exposed to different chemicals. Alcohols, sugars, amino acids and an ester that smells like pears were tested. Reporting in Open Biology, the group identified these four areas of the head as the worm’s chemosensory organs, capable of detecting different chemicals in the surrounding environment. The worm’s antennae could detect each chemical equally well, whereas three other organs responded to each chemical differently. These chemosensory organs could help the worm go about its daily business of eating, escaping from prey or reproducing. More...


 

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Open positions at the IZN

  • The research group of Dr. Carlos Bas Orth (Dept. Of Anatomy and Cell Biology / Prof. Kirsch) is searching for a highly motivated PhD student to investigate the interplay between mitochondrial calcium signaling and mitochondrial dynamics in multiple sclerosis disease progression. The project involves a broad spectrum of methods that include gene expression analysis, viral gene transfer, fluorescence live imaging in cultured neurons and retina explants, and advanced image analysis. Further information can be found here.
    posted 12.2018

  • The research group of Dr. Annarita Patrizi is searching for a highly motivated PhD student to identify intrinsic and extrinsic factors essential for development and refinement of the cortical brain circuit during normal and pathological states. The project combines state-of-the-art transcriptomic, proteomic and complex co-culture methods. Adobe
    posted 11.2018

  • Dr. Moritz Mall's team is expanding and is looking for a highly motivated recently graduated top-level PhD with a strong background in neuroscience. The project aims to understand the role of cell identity loss in brain malignancies and mental disorders that affect millions of patients worldwide and are a major medical and economic challenge to our modern society. More information can be found here.
    posted 10.2018

  • The group of Dr. Alexander Groh is looking for an outstanding scientist for the group who will lead projects, supervise students/postdocs and participate in teaching physiology (2 SWS). As this will be a key position for the group, highly motivated and ideally young candidates who will use this opportunity as a stepping stone to develop independence and to pursue an academic career are being sought. Adobe
    posted 10.2018

  • The research group of Prof. Wolfgang Sommer is searching for students to work as research assistants (HiWi, 40h/month). The group is part of the Institute for Psychopharmacology at the Central Institute of Mental Health (ZI Mannheim). Our research group is interested in the cellular and molecular basis of alcohol- and reward-seeking behavior in rats. Furthermore we are interested to characterize changes in animal behavior and cognitive functions after chronic alcohol exposure. Adobe
    posted 10.2018

  • The group of Prof. Draguhn at the Institute for Physiology and Pathophysiology is looking for a scientific research associate for neurophysiology. The applicant should be interested in studying neuronal network oscillations and functional ensembles in the hippocampus and adjacent brain areas of the rodent. The work will be at the cellular, network and behavioral levels, both in vitro and in vivo. In addition to research, the work will include teaching medical students the whole field of physiology. Adobe
    posted 09.2018

  • The Center for Biomedicine and Medical Technology Mannheim (CBTM) is seeking a full-time scientific assistant in the Department of Neurophysiology (Prof. Treede). The focus of the group is on translational pain research (models of back pain and nerve pain, diabetes consequences, signal transduction). Adobe
    posted 09.2018

  • The group of Prof.Dr. Beate Niesler is seeking a Master Thesis student to work on neurogastroenterologic disorders, resulting impairments of the enteric nervous system (ENS), the 'second brain' in our gut, and the elucidation of underlying pathomechanisms. Adobe
    posted 07.2018

  • The Department of Experimental Pain Research at the Medical Faculty Mannheim (Prof.Dr. Martin Schmelz) is offering a PhD position in a project funded by the German Science Foundation (DFG) entitled 'Selective activation of nociceptor sub-groups by slowly depolarizing electrical stimuli'. Adobe
    posted 07.2018

  • The research group of Dr. Kevin Allen is seeking a student to work as a research assistant (HiWi) on the neuronal basis of spatial behavior. The group is interested in the spatial representations generated within the mammalian brain and their contributions to spatial behavior and memory. The spatial representations generated by grid cells in the medial entorhinal cortex are a prominent example. The student will acquire experience in a wide array of techniques, including in vivo tetrode recordings in mice, data analysis, and histological analysis. Adobe
    posted 07.2018

  • The Functional Neuroanatomy group of Prof. Dr. Thomas Kuner is searching for a highly motivated PhD student to investigate the synaptic nanoarchitecture with a focus on the distribution of synaptic vesicle proteins. The project will employ a super-resolution microscopy setup (3D /d/STORM) equipped with an automated pipetting system. Adobe

    Furthermore, a Master or an MD position is open for a sub-project intended to delineate the ultrastructural organization of active zones. Adobe posted 07.2018
  • The research group of Prof. Andreas Draguhn is offering a PhD position to help untangle the molecular mechanisims by which Bcl11b/Ctip2 regulates development, maintenance and network-level functions of mossy fiber connectivitiy in CA3. The project combines state-of-the-art molecular, ultrastructural as well as electrophysiological strategies, and it will qualify PhD students both in the field of molecular/cellular neurobiology as well as cellular/systems neurophysiology. Adobe posted 06.2018
  • A PhD position is open at the Department of Neurophysiology lead by Prof. Treede to validate electrophysiological techniques on human models of pain. The main objective of the work is to improve the translatability of recordings in pain pathways of healthy subjects and preclinical species. The successful candidate will investigate the analgesic effects in the brain, the spinal cord and the peripheral nervous system. Adobe posted 05.2018
  • The research group of Dr. Sidney Cambridge (Department of Functional Neuroanatomy, Prof.Dr. Thomas Kuner) is looking for a highly motivated and well-trained student (f/m) for a Masters research project in cellular neurophysiology. The project will involve genetic manipulation of neuronal activity in a small population and assessing network changes in activity as compensatory homeostatic mechanisms. Adobe posted 05.2018
  • A PhD position in Neurobiology and Alzheimer Research is available in the laboratory of Prof. Ulrike Müller Externer Inhalt studying the synaptic roles of the APP gene family and their processing products. Techniques employed include state-of-the-art molecular biology, biochemistry, imaging and work with genetically modified mouse mutants (gain and loss of function studies) and viral vectors. Adobe posted 04.2018
  • The Ruiz de Almodóvar group is interested in the mechanisms of neurovascular development in mice and is looking for a motivated HiWi student to help with basic experimental techniques such as mouse genotyping, cell culture and histology. Adobe posted 03.2018
  • The Developmental Neurobiology group of Prof. Elisabeth Pollerberg is looking for a highly motivated postdoc whose project will focus on the interactions of cell adhesion molecules with other types of proteins and the impact of these interactions on axon elongation and navigation. Substantial amounts of data have already been collected for several projects and the postdoc is expected to complete and publish these studies. In addition, a new translational project could be started aiming at the improvement of axon regeneration. Adobe posted 02.2018

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Contact

Managing Director:
Prof. Dr. Hilmar Bading
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16500
Fax:  +49 - 6221 - 54 16524
email:  Bading@nbio.uni-heidelberg.de

 

Coordinator:
Dr. Otto Bräunling
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16502, 56 39007
Fax:  +49 - 6221 - 54 16524
email:  Braeunling@nbio.uni-heidelberg.de

 

Administration & Information:
Irmela Meng
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16501
Fax:  +49 - 6221 - 54 16524
email:  Sekretariat@nbio.uni-heidelberg.de
Webmaster contact: WebmasterIZN@uni-heidelberg.de
Latest Revision: 2019-01-21
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