11.09.2019      13:00

IZN Seminar




Im Neuenheimer Feld 306

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Neuronal vulnerability and multilineage diversity in multiple sclerosis

Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing–remitting disease course at early stages, distinct lesion characteristics in cortical grey versus subcortical white matter and neurodegeneration at chronic stages. Lucas Schirmer used single-nucleus RNA sequencing to assess changes in expression in multiple cell lineages in MS lesions and validated the results using multiplex in situ hybridization. His findings have been published in Nature Externer Inhalt

Human blood cells can be directly reprogrammed into neural stem cells

Foto © M.C. Thier/DKFZ

Scientists from the German Cancer Research Center (DKFZ) and the stem cell institute HI-STEM* in Heidelberg have succeeded for the first time in directly reprogramming human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the early embryonic development of the central nervous system. They can be modified and multiplied indefinitely in the culture dish and can represent an important basis for the development of regenerative therapies.

Together with stem cell researcher Frank Edenhofer from the University of Innsbruck and neuroscientist Hannah Monyer from DKFZ and the Heidelberg University Hospital, Andreas Trumpp (German Cancer Research Center (DKFZ) and Director of HI-STEM in Heidelberg) and his team have succeeded in reprogramming different human cells: connective tissue cells of the skin or pancreas as well as peripheral blood cells. "The origin of the cells had no influence on the properties of the stem cells," said Marc Christian Thier, first author of the study. In particular, the possibility of extracting neural stem cells from the blood of patients without invasive intervention is a decisive advantage for future therapeutic approaches. More...


Open positions at the IZN

  • The Puttagunta group is seeking a highly motivated and qualified M.Sc. student to start a PhD project, the goal of which is to understand the underlying mechanisms that transpire after spinal cord injury that lead toward half of all spinal cord injury patients suffering from neuropathic pain. Methods that will be used: intersectional genetics, cell-specific ablations, use of reporter lines, monosynaptic tracing, tissue clearing and 3D microscope reconstruction, behavioural pain assessments and histology. Adobe
    Posted 07.2019

  • The Acuna group and Katrin Schrenk-Siemens are seeking 2 highly motivated postdoc candidates to work on the recently funded project 'Human pluripotent stem cell-derived neurons as a tool to study central and peripheral nociceptive mechanisms' using RNAseq, electrophysiology, imaging, and super-resolution microscopy. Adobe
    Posted 06.2019

  • The group of Prof. Andreas Draguhn is looking for an outstanding PhD student for a pathophysiological study in cellular neurophysiology to study changes in retinal function following experimental autoimmune optic neuritis, with particular emphasis on alterations in synaptic transmission and glutamate homeostasis. Methods include cellular electrophysiology, microscopy, viral transduction and histological/morphological techniques. Adobe
    Posted 02.2019



Managing Director:
Prof. Dr. Hilmar Bading
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16500
Fax:  +49 - 6221 - 54 16524
email:  Bading@nbio.uni-heidelberg.de


Dr. Otto Bräunling
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16502
Fax:  +49 - 6221 - 54 16524
email:  Braeunling@nbio.uni-heidelberg.de


Administration & Information:
Irmela Meng
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16501
Fax:  +49 - 6221 - 54 16524
email:  Sekretariat@nbio.uni-heidelberg.de
Webmaster contact: WebmasterIZN@uni-heidelberg.de
Latest Revision: 2019-08-20
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