Monday, 23.07.2018    15:00

Nbio Lecture


Multiscale-Multimodal Imaging of the Brain: Revealing Secrets Hiding in Plain Sight


Mark H. Ellisman, Ph.D.
Senior Fellow, HHMI Janelia Research Campus;
Director, National Center for Microscopy and Imaging Research (NCMIR), UCSD, USA


A grand goal in brain research is to understand how the interplay of structural, chemical and electrical signals in and between neurons, glia and the vasculature give rise to normal and abnormal functioning of nervous systems. New technologies are hastening progress as biologists make use of an increasingly powerful arsenal of tools and technologies for obtaining data, from the level of molecules to whole organs.

This talk will highlight projects in which development and application of new contrasting methods and imaging tools have allowed us to observe otherwise complex or hidden relationships between cellular, subcellular and molecular constituents of cells, particularly those comprising the brain. Prospects for enhancing our understanding of the complex physiology of multiscale systems by facilitating the application of multimodal imaging methods as well as the fusion of data obtained using multiple methods, will also be discussed.


SR25, Im Neuenheimer Feld 328, Heidelberg


25.07.2018    13:00

IZN Seminar


Influence of the interaction of trauma and resilience traits on reward-related functional activity in humans using fMRI

Anja Richter (AG Gruber)


Re-STORM: Repeated Multi-Target Super-Resolution Microscopy

Maja Klevanski (AG T.Kuner)


HS2, Im Neuenheimer Feld 306, Heidelberg


Welcome to the IZN Home Page
Selected cells
Kuner T Fig1
Pauen Fig1
Poggi Figure2
Rappold Fig1
Holstein Fig1

IZN Retreat July 2018


And the winners are:

2018maxrichterizn-chsyounginvestigatorneuroscience 2018diegobenusiglioiznposter 2018melinacastelanellifoundationbrainaid

IZN / Chica and Heinz Schaller Young Investigator Neuroscience Award:

Max Richter

IZN Students Poster Prize:

Diego Benusiglio

Diego Benusiglio, Yan Tang, Shiyi Wang, Xinying Liu, Valery Grinevich: Sensory-driven activation of oxytocin neurons during social interaction

Foundation BrainAid IZN Master’s Award 2018:

Melina Castelanelli

Evaluation of neuronal optogenetic manipulation in vitro and in freely moving mice

Photos by Jing Yan, IZN Neurobiology. All photos here.

IZN Chica and Heinz Schaller Young Investigator Neuroscience Award zum dritten Mal vergeben

Anlässlich des jährlichen Retreats des Interdisziplinären Zentrums für Neurowissenschaften (IZN) im Kloster Schöntal wurde am 02.07.18 zum dritten Mal der IZN Chica and Heinz Schaller Young Investigator Neuroscience Award für eine herausragende Publikation auf dem Gebiet der Neurowissenschaften vergeben. Der Preis ist mit 1.000 Euro dotiert und benannt nach den Stiftern, Frau Professor Chica Schaller und Herrn Professor Heinz Schaller (†2010), die beide am Wissenschaftsstandort Heidelberg tätig waren und als Pioniere der modernen Molekularbiologie und Neurobiologie gelten.

Preisträger ist der 29-jährige Max Richter, der für seine im April 2018 erschienene Arbeit „Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition“ ausgezeichnet wurde. Diese Arbeit wurde in der renommierten Zeitschrift „EMBO Journal“ publiziert, darüber hinaus wurde eine Gewebsfärbung aus der Arbeit für das Titelbild der Zeitschrift ausgewählt.

Das Preiskomitee begründet seine Entscheidung wie folgt: Die Studie von Herrn Richter und seinen Kolleginnen und Kollegen zeigt einen neuen, potentiell therapeutisch nutzbaren Ansatz, die Alzheimer Erkrankung zu behandeln. Dazu wurde ein Protein identifiziert, welches das Denkvermögen und die Merkfähigkeit im Modell der Alzheimer Erkrankung verbessert. Dieses Protein ist ein Spaltprodukt des sog. Amyloid Precursor Proteins, dem bisher eine ausschließlich negative, krankheits-begünstigende Funktion zugeschrieben wurde. Vor dem Hintergrund der in jüngster Vergangenheit fehlgeschlagenen großen multizentrischen Studien zur Alzheimer Erkrankung und der Entscheidung zahlreicher pharmazeutischer Unternehmen, ihre Forschung auf dem so wichtigen Gebiet der Alzheimer Erkrankung zu stoppen, würdigt das Preiskomitee den engagierten Einsatz universitärer Forscher wie Herrn Richter, die dem Feld der Alzheimer Forschung neue Impulse und Hoffnung geben.

Hannah Monyer erhält den Akademiepreis 2018 der Berlin-Brandenburgischen Akademie der Wissenschaften

MonyerBerlin, 25. Juni 2018. Der mit 50.000 Euro dotierte Akademiepreis der Berlin-Brandenburgischen Akademie der Wissenschaften für herausragende wissenschaftliche Leistungen geht in diesem Jahr an die Neurowissenschaftlerin Prof. Dr. Hannah Monyer, Leiterin der Abteilung Klinische Neurobiologie, Deutsches Krebsforschungszentrum (DKFZ) Heidelberg und Medizinische Fakultät der Universität Heidelberg. Der Preis gehört zu den höchsten Auszeichnungen, welche die Akademie zu vergeben hat. Die Preisverleihung findet am 30. Juni 2018 im Rahmen der Festsitzung zum Leibniztag statt.

Die herausragenden wissenschaftlichen Leistungen Hannah Monyers beruhen darauf, dass sie in bewundernswerter Weise zentrale Fragen der Hirnforschung stets mit einem Repertoire von fortgeschrittensten experimentellen Methoden u.a. aus der Gentechnik, der Optogenetik und der Elektrophysiologie angeht. Mehr...

Researchers discover receptor for the protein fragment APPsα mediating its physiological function

A cleavage product of the Alzheimer's APP protein stimulates nerve cell communication and memory. The protein fragment, known as APPsα, has neuroprotective properties and acts as a signal molecule on other nerve cells. But how does it influence brain functions?

An international research team led by Prof. Dr Ulrike Müller Externer Inhalt of the IZN has gained new insights into the molecular mechanism underlying its physiological functions. Full article...Externer Inhalt

Photo: Max Richter, Müller research group
Neuroprotective role of APPsα: A histological section through the hippocampus is depicted in the background. The red staining shows APPsα in neuronal cell bodies. The green staining shows the dendritic processes of nerve cells.

EMBL scientists discover how a molecule’s role changes from simple metabolite to instructive signal

ArendtAmong developmental biologists, the signalling molecule retinoic acid is well known for its role in building the vertebrate body. Not much is known, however, about how such signals emerge in evolution. To investigate this, the IZN's Detlef Arendt Externer Inhalt lab at EMBL in Heidelberg has studied the role of retinoic acid signalling in a marine worm. In the study published in Science Advances Externer Inhalt, the team and its collaborators show that in the worm, retinoic acid acts like a metabolic timer that helps neurons to form at the right time and place during development.

Image: Mette Handberg-Thorsager/EMBL



Open positions at the IZN

  • The Functional Neuroanatomy group of Prof. Dr. Thomas Kuner is searching for a highly motivated PhD student to investigate the synaptic nanoarchitecture with a focus on the distribution of synaptic vesicle proteins. The project will employ a super-resolution microscopy setup (3D /d/STORM) equipped with an automated pipetting system. Adobe

    Furthermore, a Master or an MD position is open for a sub-project intended to delineate the ultrastructural organization of active zones. Adobe posted 07.2018
  • The research group of Prof. Andreas Draguhn is offering a PhD position to help untangle the molecular mechanisims by which Bcl11b/Ctip2 regulates development, maintenance and network-level functions of mossy fiber connectivitiy in CA3. The project combines state-of-the-art molecular, ultrastructural as well as electrophysiological strategies, and it will qualify PhD students both in the field of molecular/cellular neurobiology as well as cellular/systems neurophysiology. Adobe posted 06.2018
  • The research group of Dr. Kevin Allen is seeking a highly motivated PhD student to work on the neuronal basis of spatial behavior. The student will use a wide array of techniques to study system neuroscience, including in vivo tetrode recordings in mice, optogenetics, behavioral testing, analysis of large databases and histological analysis. Adobe posted 05.2018
  • A PhD position is open at the Department of Neurophysiology lead by Prof. Treede to validate electrophysiological techniques on human models of pain. The main objective of the work is to improve the translatability of recordings in pain pathways of healthy subjects and preclinical species. The successful candidate will investigate the analgesic effects in the brain, the spinal cord and the peripheral nervous system. Adobe posted 05.2018
  • The research group of Dr. Sidney Cambridge (Department of Functional Neuroanatomy, Prof.Dr. Thomas Kuner) is looking for a highly motivated and well-trained student (f/m) for a Masters research project in cellular neurophysiology. The project will involve genetic manipulation of neuronal activity in a small population and assessing network changes in activity as compensatory homeostatic mechanisms. Adobe posted 05.2018
  • A PhD position in Neurobiology and Alzheimer Research is available in the laboratory of Prof. Ulrike Müller Externer Inhalt studying the synaptic roles of the APP gene family and their processing products. Techniques employed include state-of-the-art molecular biology, biochemistry, imaging and work with genetically modified mouse mutants (gain and loss of function studies) and viral vectors. Adobe posted 04.2018
  • The Ruiz de Almodóvar group is interested in the mechanisms of neurovascular development in mice and is looking for a motivated HiWi student to help with basic experimental techniques such as mouse genotyping, cell culture and histology. Adobe posted 03.2018
  • The Developmental Neurobiology group of Prof. Elisabeth Pollerberg is looking for a highly motivated postdoc whose project will focus on the interactions of cell adhesion molecules with other types of proteins and the impact of these interactions on axon elongation and navigation. Substantial amounts of data have already been collected for several projects and the postdoc is expected to complete and publish these studies. In addition, a new translational project could be started aiming at the improvement of axon regeneration. Adobe posted 02.2018



Managing Director:
Prof. Dr. Hilmar Bading
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8218
Fax:  +49 - 6221 - 54 6700


Dr. Otto Bräunling
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8694, 56 39007
Fax:  +49 - 6221 - 54 6700


Administration & Information:
Irmela Meng
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 364, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 8219
Fax:  +49 - 6221 - 54 6700

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Latest Revision: 2018-07-17
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